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2

抑制剂 & 化合物

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重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T70049 Ro 04-5595 free base

Ro 04-5595 is a selective antagonist of NMDA receptors NR2B subunits. Ro 04-5595 had an EC 50 of 186 ± 32 nmol/L. Ro 04-5595 was predicted to bind the EVT-101 binding site, not the ifenprodil-binding site. Specific binding, defined with a new NR2B-specific antagonist Ro 04-5595 at 10 microM was fully inhibited by several compounds with the following rank order of affinities--Ro 25-6981 > CP-101,606 > Ro 04-5595 = ifenprodil >> eliprodil > haloperidol > spermine > spermidine > MgCl2 > CaCl2--and...
T23239 Ro 04-5595 hydrochloride

Others Others
NR2B-containing NMDA receptors antagonist

化合物

Ro 04-5595 free base
Cat.No: T70049
Synonym:
Target:
Ro 04-5595 hydrochloride
Cat.No: T23239
Synonym:
Target: Others
Cat. No. Product Name Species Expression System
TMPJ-00662 RANKL/TNFSF11/CD254 Protein, Human, Recombinant (E. coli)

Receptor activator of nuclear factor kappa-B l<...

Human E. coli
CD254, also known as RANKL, TNFSF11, TRANCE, OPGL and ODF, is a type II membrane protein of the tumor necrosis factor (TNF) superfamily, and affects the immune system and control bone regeneration and remodeling. RANKL is the ligand of nuclear factor (NF)-κB (RANK). When RANKL binds to RANK, it will undergo trimerization and then bind to an adaptor molecule TNF receptor-associated factor 6 (TRAF6). This results in the activation of several downstream signaling cascades, including the NFκB, mitog...
TMPJ-00253 OPG Protein, Mouse, Recombinant (His)

Opg,Ocif,Tnfrsf11b,Osteoclastogenesis inhibitory fa...

Mouse HEK293 Cells
Osteoprotegerin (OPG, Tnfrsf11b) is a secreted protein that regulates bone density. OPG is widely expressed and constitutively released as a homodimer by mesenchymal stem cells, fibroblasts and endothelial cells. Regulation of its expression by estrogen, parathyroid hormone and cytokines is complex and changes with age. OPG acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. TRAIL decreases the release of OPG from cells that express it, while OPG ...

重组蛋白

RANKL/TNFSF11/CD254 Protein, Human, Recombinant (E. coli)
Cat.No: TMPJ-00662
Species: Human
Expression System: E. coli
OPG Protein, Mouse, Recombinant (His)
Cat.No: TMPJ-00253
Species: Mouse
Expression System: HEK293 Cells
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